The present study was performed to design the sustained release muco-adhesive oral tablet of propranolol HCl. The study was aimed to increase the residence time of the drug in to the stomach and release for extended period of time in order to increase bioavailability of the drug, reduce dosing frequency, improve patient compliance and optimization of drug release profile. The study was performed on three different polymer i.e. Hydroxy propyl methyl cellulose (HPMC), Sodium carboxy methyl cellulose (Na CMC) and Carbopol. All the 13 formulations (F1 to F13) were evaluated for their physical parameters with regard to thickness uniformity, hardness, friability, weight variation and drug content determination. All the prepared formulation had shown the satisfactory results. The muco-adhesion force for all the prepared formulations was found in the range of 0.58 N to 3.43 N. Formulation containing combination of polymer shows greater muco-adhesion as compare to other formulations. The linear relationship was found between concentration of polymer & swelling index. Dissolution studies revealed that release rate was inversely related to polymer concentration down the dissolution rate. Statistical data shows drug release occurred via diffusion mechanism from hydrophilic polymers like Carbopol and HPMC. Stability study performed according to ICH guideline shows negligible changes in drug release and drug content after the period of three months.
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